Assessment of the hereditary component of fluoride ecotoxic load
V.I. Starichenko
Section: Ecotoxicology
Fluoride is one of the most toxic and widely spread industrial pollutants of the environment. Identifying the hereditary component of fluoride accumulation plays a special role in environmental issues of fluoride pollution, as contributing to maintaining its level across generations. However, the factors of individual variability of fluoride accumulation in mammals, in particular, the hereditary component of accumulation variability, have not been identified. This is due to the methodological features of studying fluoride deposition parameters that are inaccessible in direct environmental observations. An experimental study on laboratory mice allows us to estimate the magnitude of the hereditary component of fluoride deposition. The fluoride accumulation was studied in the progeny of three strains of inbred mice (intrastrain correlation) against the background conditions and following chronic intake of the toxicant. The variant of the family analysis (intrafamily correlation) was also used. It is a classical approach to the hereditary variation of quantitative traits assessment. Fluoride entered the female mice body with food during the whole gestation period and up to the age of 1.5 month of the progeny. The assessment was performed with the control of the animal sex and litter size effect. Individual parameters of fluoride accumulation differed in certain experimental groups by 3–6.5 times. At the same time the specifics of fluoride accumulation was typical of the entire families. Combined hereditary component (intrastrain and intrafamily) of the fluoride accumulation was comparable with the hereditary correlation of morphological characteristics with known hereditary dependence of development (R = 0.50–0.56, p < 0.0001 and R = 0.45–0.53–0.58, p < 0.0001 respectively). Notably, the family component of the variability depending on the analysis option (the entire sample or just the experimental group) is comparable and exceeds the animal’s strain effect by 2–3 times. For background fluoride level the hereditary dependence of its deposition is statistically insignificant. The results obtained can be extrapolated to field rodents.
ISSN 1995-4301
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